Author

Valentina A. Spiteri

University of DundeeORCID 0000-0002-5002-4989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alessio CiulliiD· 3 shared Mark A. NakasoneiD· 2 shared William FarnabyiD· 2 shared Aileen B. FrostiD· 1 shared Alejandro Correa-SáeziD· 1 shared Alena KroupovaiD· 1 shared Andre J. WijayaiD· 1 shared Andrea Stingu· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

Alessio CiulliORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 4, 2025

Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4

Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-Sáez…·Georg E. Winter

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

7 citations

humanproteomics

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BiochemistryNature CommunicationsPeer-reviewedOct 15, 2024

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter…·Alessio Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

53 citationstop 2%

protein structureexperimental assay

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Cancer BiologyACS Chemical BiologyPeer-reviewedJul 3, 2024

Confounding factors in targeted degradation of short-lived proteins

Vesna Vetma, Laura Casares Perez, Ján Eliaš…·Manfred Koegl

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.

53 citationstop 2%

statistical modeldrug response / drug discovery

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