Author

Alexandra Rose Teagle

Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh, UKORCID 0000-0002-4674-7260Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

David WrightiD· 1 shared Nicola Logan· 1 shared Patricia Castro-SancheziD· 1 shared Rebecca J Brownlie· 1 shared Robert J SalmondiD· 1 shared Rose ZamoyskaiD· 1 shared Simran S Kapoor· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

David WrightORCID

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1 paper

Recent·Most cited

ImmunologybioRxivJun 24, 2023

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion

Alexandra Rose Teagle, Patricia Castro-Sanchez, Rebecca J Brownlie…·Rose Zamoyska

This study shows that deleting PTPN22 in T cells enhances initial anti-tumor effector function but accelerates T cell exhaustion, with TIM-3 expression linked to IL-2 signaling and NFIL3.

DOI 10.1136/jitc-2023-007614

mouseproteomics

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