Laura E. Herring

This study shows that deletion of the septin gene aspB in Aspergillus fumigatus makes it susceptible to the fungistatic drug caspofungin, converting it to a fungicidal effect.

The paper shows that pro-inflammatory microglia increase IRF7 levels and ethanol self-administration in rats during early abstinence, which is reduced by minocycline treatment.

This study identifies chromatin regulators of HIV latency and reactivation using RelB proximity proteomics and CRISPR screening, revealing key acetyltransferases involved in noncanonical NF-κB pathway activation.

The paper describes a penta-omic sequential extraction method for post-mortem human brain samples, showing minimal omic loss and preserved tissue integrity compared to single-omic methods.

This study identifies APOE interacting with COX-2 on lipid droplets, showing APOE3 promotes and APOE4 suppresses COX-2 activity and prostaglandin production.

This study shows USP7 inhibition disrupts proteostasis and tumor growth in triple negative breast cancer by stabilizing E3 ubiquitin ligases and affecting DNA repair pathways.

The paper identifies phosphorylation of endomembrane proteins in closed guard cells, suggesting their role in regulating stomatal closure.

This study identifies PRAME as a therapeutic target in NUT carcinoma, showing its high expression and susceptibility to T-cell mediated cytotoxicity via PRAME epitopes presented by HLA Class I molecules.

The paper examines non-redundant roles of paralogous proteins in yeast glucose-sensing pathways through gene deletion and multi-omics analyses.

This study identifies RNF25's role in protecting DNA replication forks from degradation, independent of its ubiquitin signaling functions.

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

This study examines temporal changes in extracellular vesicle (EV) protein cargo in burn-injury patients and mice, showing distinct immune reprogramming effects at early and late post-injury stages.

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.

This study identifies MAPK14/p38α as critical for HGEC spheroid growth, shaping its transcriptomic, proteomic, and metabolomic landscapes and promoting tumorigenic properties.

This study examines the effects of sleep deprivation on synaptic vulnerability across developmental stages in mice, finding heightened sensitivity in juveniles and links to ASD risk.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The paper identifies SMN complex binding partners and reveals conserved connections to chaperone systems, linking chaperone dysfunction to ALS and SMA.

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

The paper demonstrates that TRAIL-loaded exosomes from induced neural stem cells effectively target and kill brain cancer cells in vitro and in vivo.

This study identifies hyperactivation of innate immune signaling as a consequence of SMN depletion in Drosophila SMA models, revealing a conserved regulatory role of the SMN complex.

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

This study shows TRIM9 localizes to dendritic spines and regulates actin dynamics and synaptic responses to netrin-1 during synaptogenesis.

This study shows TRIM67 localizes to the post-synaptic density and its loss alters the PSD proteome and cytoskeletal regulation.

The paper shows a monoclonal antibody against EZH2 cross-reacts with SAFB, highlighting the need for orthogonal assays in studying RNA-chromatin interactions.

This study identifies SAFB-associated RNAs in mouse embryonic stem cells and shows SAFB promotes gene expression by binding purine-rich regions in nascent transcripts.

The paper uses quantitative proteomics to study murine embryonic heart development and identifies the mevalonate pathway's role in cardiomyocyte proliferation.