Klaus‐Peter Janssen

The paper identifies metastatic founder cell candidates in bone marrow that resemble preimplantation embryonic blastomeres, linking cancer metastasis to early embryonic development mechanisms.

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.

This study investigates how ER stress signaling contributes to therapy resistance in colorectal cancer by analyzing genomic alterations and testing therapeutic responses in cell lines and organoids.