Nahum Sonenberg

This study identifies a synergistic therapeutic effect of combining MNK1/2 inhibition with G1/S CDK blockade in triple-negative breast cancer.

This paper shows that viral inhibition of the APC/C enhances replication by increasing nucleotide pools through stabilization of biosynthesis enzymes.

The paper identifies a shared CNOT1 binding site used by GW182 and TTP, revealing SLiM-mediated competition in CCR4-NOT complex recruitment.

This study shows that GIGYF2/4EHP-mediated translational repression helps maintain cellular homeostasis after ionizing radiation by preserving proteostasis and cell viability.

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

This study shows that 4E-BP2 controls specific mRNA translation in GABAergic interneurons, which is necessary for long-term memory formation.

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

The paper identifies ITAF45 as a host factor essential for picornavirus Type II IRES-mediated translation, showing its role in multiple viruses and suggesting it as an antiviral target.

The paper shows that human GIGYF2 does not interact with GRB10, challenging the current understanding of their role in disease.

The paper investigates the role of FMRP in neuronal RNA granules containing stalled ribosomes and finds that its loss affects granule stability but not ribosome stalling sites.

This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

This study identifies EDC-3 and EDC-4 as regulators of mRNA decay and biomolecular condensate specialization during C. elegans embryonic development.

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

This study identifies the mTORC1-4E-BP1 axis as a neuroprotective mechanism in microglia under AD conditions, showing its role in suppressing inflammation and neurodegeneration.

This study shows that p38γ and p38δ regulate innate immune responses by modulating MEF2D phosphorylation and transcriptional activity in mice.

The paper identifies the RagA-mTORC1 network as a key driver of neuropathic pain through cell-specific translational profiling in nociceptors.