Frederik J. Steyn

The paper quantifies UFMylation sites in mouse tissues and ALS patient biopsies, finding increased myosin UFMylation in ALS.

This study characterizes the skeletal muscle arginine methylome in health and disease, revealing significant remodeling in ALS and identifying potential therapeutic targets.

The paper identifies tissue-informative DNA methylation sites in ALS using targeted sequencing and machine learning, showing accurate prediction of disease status and progression.

The paper performs RNA-seq analysis of skeletal muscle in ALS patients and controls to identify differentially expressed genes and isoform switches associated with motor neuron disease.

This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.