Hideki Kandori

This study demonstrates that potassium channelrhodopsins function as H+ pumps and channels, with their activity modulated by light and environmental ions.

This paper identifies a coral opsin, AtAntho2c, that can autonomously regenerate its inactive state through thermal isomerization of retinal, enabling repeated light responses without exogenous retinal.

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

This study presents cryo-EM structures of ChR024, revealing its color-tuning mechanism and transition from a proton pump to a light-gated channel.

The paper reports the cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens and develops mutants with blue-shifted action spectra.

The paper reports light energy transfer from hydroxylated carotenoids to heimdallarchaeial rhodopsins in marine archaea, showing light-harvesting capabilities in archaea similar to bacterial rhodopsins.

The paper demonstrates the use of microbial rhodopsins and adenylyl cyclases to control second messengers in zebrafish neurons and cardiomyocytes, revealing their roles in locomotion and cardiac function.

This paper demonstrates the use of X-ray-induced scintillation to remotely control neural function in mice, achieving bidirectional modulation of behavior through optogenetic activation and inhibition.

The paper demonstrates that ectopic expression of chimeric rhodopsin in mice restores dim-light vision and prevents retinal degeneration.

The paper uses machine learning to predict and understand the absorption wavelengths of microbial rhodopsins by analyzing sequence and functional data.