Pau Castel

This paper constructs a spatial regulatory atlas of glioblastoma by integrating transcriptional data with drug target predictions to identify niche-specific therapeutic vulnerabilities.

This study shows that USP9X stabilizes RIT1 protein and that its depletion reduces RIT1 abundance and sensitizes cells to EGFR inhibitors.

The paper analyzes LZTR1 loss-of-function mutants in fruit flies and mice, showing dependency on RIT1 orthologs and haplosufficiency in mice.