Colin J. Raposo

This study shows that exhausted T cells can form functional memory T cells after antigen clearance, and checkpoint blockade expands these memory clones.

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

This paper designs novel transcription factors using evolutionary principles to generate T cell states with enhanced functionality.