Isabell Niedermoser

This study shows that phosphorylation of IGF2BP1 at S181 and Y396 modulates RNP condensate formation by altering low-affinity interactions with RNA and protein partners.

The paper shows that β-catenin signaling patterns the oral-aboral axis in Nematostella vectensis, but endoderm specification occurs opposite to nuclear β-catenin accumulation, suggesting this mechanism is a Bilateria-specific co-option.

The paper shows that four Frizzled receptors in Nematostella vectensis have partially redundant roles in oral-aboral axis patterning via cWnt signaling, but not in endoderm specification.

The paper investigates β-catenin-dependent axial patterning in Nematostella and finds similar regulatory logic to deuterostomes, suggesting a common evolutionary origin.