ImmunologybioRxivPreprint
PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.
Magdalena G. Grzemska, Luming Chen, Jamie L. Russell…·Evan Nair‐Gill
DOI 10.64898/2026.03.16.712247
Author
The University of Texas Southwestern Medical CenterORCID 0000-0002-5306-3553Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Magdalena G. Grzemska, Luming Chen, Jamie L. Russell…·Evan Nair‐Gill
Le Xiao, Magdalena G. Grzemska, Xiong Pi…·Evan Nair‐Gill
This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.
Clinton A. Taylor, Ji-Ung Jung, Sachith Gallolu Kankanamalage…·Melanie H. Cobb
The paper identifies interaction motifs of the WNK-OSR1/SPAK pathway and validates their function through experimental testing.