PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.
Magdalena G. Grzemska, Luming Chen, Jamie L. Russell…·Evan Nair‐Gill
Author
The University of Texas Southwestern Medical CenterORCID 0000-0002-9876-7853Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Magdalena G. Grzemska, Luming Chen, Jamie L. Russell…·Evan Nair‐Gill
Le Xiao, Magdalena G. Grzemska, Xiong Pi…·Evan Nair‐Gill
This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.
Jamie Russell, Luming Chen, Aijie Liu…·Evan Nair‐Gill
This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.
Darui Xu, Stephen Lyon, Chun Hui Bu…·Bruce Beutler
Candidate Explorer identifies causative mutations for immune phenotypes by integrating multiple data features into a score, improving mutation-phenotype association verification in mice.