Sabine Wilhelm

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

This study identifies TANGO1 as a selective ECM cargo receptor that directly recognizes specific collagen and fibrillin isoforms through a conserved tyrosine residue, independent of HSP47.

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.

This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.