Manolis Pasparakis

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

This study shows that different modes of macrophage cell death affect wound healing outcomes, with necroptosis impairing repair and apoptosis promoting better tissue recovery.

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.