Constantinos Demetriades

This study identifies TANGO1 as a selective ECM cargo receptor that directly recognizes specific collagen and fibrillin isoforms through a conserved tyrosine residue, independent of HSP47.

This study identifies GRASP55 as a key regulator of lysosome function by controlling lysosomal enzyme sorting at the Golgi, revealing its role in lysosomal mTORC1 signaling and potential involvement in lysosomal storage disorders.

The paper identifies ATM-dependent RHEB phosphorylation as a mechanism linking DNA damage to lysosomal mTORC1 signaling, which regulates TFEB and lysosome biogenesis during genotoxic stress.

This study identifies TSC1 as a direct mTORC1 substrate, revealing a minimal autoregulatory feedback loop that selectively controls lysosomal mTORC1 signaling.

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.

The paper shows that hil-1/H1-0, a nutrient-regulated linker histone, mediates resilience and restoration during fasting-refeeding in C. elegans and human cells.

This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.

The paper identifies a splicing factor mutation that enhances longevity in C. elegans by causing intron retention and inhibiting mTOR signaling.