Author
Max Planck Institute for Biology of AgeingORCID 0009-0003-7443-5621Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Jiyoung Pan, Aurelio A. Teleman, Constantinos Demetriades
The paper identifies ATM-dependent RHEB phosphorylation as a mechanism linking DNA damage to lysosomal mTORC1 signaling, which regulates TFEB and lysosome biogenesis during genotoxic stress.
Stephanie Fernandes, Jiyoung Pan, Diana S. Terziyska…·Constantinos Demetriades
This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.
Stephanie Fernandes, Danai-Dimitra Angelidaki, Julian Nüchel…·Constantinos Demetriades
This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.