Alessandro Fantin

The paper identifies a Csf1r lineage contributing to 60% of embryonic dermal lymphatic endothelial cells and shows its necessity for normal lymphatic development.

The paper identifies a transient population of Pax3 lineage cells in the mouse fetal liver and circulation with haematopoietic progenitor characteristics and the ability to generate myeloid and erythroid cells.

The paper identifies hemogenic endothelium in vitelline and umbilical arteries as a major source of fetal lympho-myeloid progenitors in mice, showing their transient contribution before definitive HSCs emerge.

BulkECexplorer compiles bulk RNAseq data from vascular endothelial cells to predict gene activity or leakiness across five subtypes.

The paper identifies NRP1-expressing myeloid cells as promoters of arteriogenesis in ischemic limbs and suggests their therapeutic potential.

This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.

The paper generates a refined single-cell landscape of haematopoiesis in the mouse foetal liver using scRNA-seq, identifying new cell populations and transcriptional dynamics.

The paper shows KIT is required for fetal liver erythropoiesis but not for yolk sac endoHT or brain angiogenesis.