PhysiologybioRxivPreprint
Targeting NRP1 with EG00229 induces neurovascular permeability
Silvia Dragoni, James T. Brash, Alessandro Fantin…·Christiana Ruhrberg
This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.