Author

James T. Brash

University College LondonORCID 0000-0003-0420-031XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandro FantiniD· 2 shared Christiana RuhrbergiD· 2 shared Charles BurridgeiD· 1 shared Chiara Colletto· 1 shared Guillermo Diez-PineliD· 1 shared Laura DentiiD· 1 shared Patric TurowskiiD· 1 shared Raphaël F. P. CastellaniD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Alessandro FantinORCID

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2 papers

Recent·Most cited

BioinformaticsNature Cardiovascular ResearchPeer-reviewedMar 13, 2024

BulkECexplorer: a bulk RNAseq compendium of five endothelial subtypes that predicts whether genes are active or leaky

James T. Brash, Guillermo Diez-Pinel, Chiara Colletto…·Christiana Ruhrberg

BulkECexplorer compiles bulk RNAseq data from vascular endothelial cells to predict gene activity or leakiness across five subtypes.

11 citations

𝕏 PostBluesky

PhysiologybioRxivPreprintNov 7, 2023

Targeting NRP1 with EG00229 induces neurovascular permeability

Silvia Dragoni, James T. Brash, Alessandro Fantin…·Christiana Ruhrberg

This study shows that EG00229, designed to inhibit VEGF-NRP1 interaction, paradoxically increases vascular leakage by activating NRP1-dependent signaling pathways.

4 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky