Author

Lijing Zhang

Westlake UniversityORCID 0000-0002-5541-3051Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

Qi HuiD· 2 shared Chen PengiD· 1 shared Hannan Luo· 1 shared Hongtao YuiD· 1 shared Jing HuangiD· 1 shared Ningke HouiD· 1 shared Pei‐Yong ShiiD· 1 shared Runtong QianiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Qi HuORCID

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2 papers

Recent·Most cited

MicrobiologyCell DiscoveryPeer-reviewedApr 9, 2024

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Lijing Zhang, Xuping Xie, Hannan Luo…·Qi Hu

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

34 citationstop 1%

virusexperimental assay

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Synthetic BiologyMicrobiology SpectrumPeer-reviewedJun 27, 2022

BRET-based self-cleaving biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery

Ningke Hou, Chen Peng, Lijing Zhang…·Qi Hu

The paper develops BRET-based biosensors for evaluating SARS-CoV-2 3CLpro inhibitors in BSL-2 labs, showing they correlate with known inhibitor activities.

13 citations

protein structureexperimental assay

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