Runtong Qian

This paper introduces AFLF, a method to generate diverse protein conformations from sequence using AlphaFold's latent space, showing it captures structural fluctuations and binding sites.

This paper introduces ErePOC, a contrastive learning model for representing protein binding pockets, which improves DEL target selection by identifying shared characteristics and functional similarities.

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.