Xuping Xie

The paper analyzes the functional and structural characteristics of the SARS-CoV-2 BA.3.2.1 spike, showing trade-offs between immune evasion and replication fitness.

The paper screens TLR signaling inhibitors to identify compounds affecting stress granules and finds PPM18, which inhibits Influenza A Virus without relying on stress granule formation.

This study shows that disrupting both NSP3 and nucleocapsid SG antagonism reduces SARS-CoV-2 replication and disease, suggesting stress granule activation as a therapeutic target.

This study develops VSA-2, a plant-derived adjuvant for SARS-CoV-2 subunit vaccines, showing it induces strong immune responses and protection comparable to QS-21.

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

This study investigates prolonged neurological effects in AC70 hACE2 Tg mice infected with Omicron BA.1, showing BBB disruption, neuroinflammation, and coagulopathy contribute to long-COVID-like symptoms.

This study identifies how NITD-688 inhibits dengue virus by binding NS4B and disrupting its interaction with NS3, reducing viral replication.

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

This paper develops first-in-class PROTAC degraders of SARS-CoV-2 main protease, showing they reduce MPro levels and exhibit anti-SARS-CoV-2 activity.

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

This study compares the neutralization evasion of SARS-CoV-2 variants BA.2.86, XBB sublineages, and CH.1.1, finding BA.2.86 less evasive than XBB sublineages but CH.1.1 most evasive.