Author
University of BirminghamORCID 0000-0002-5605-0395Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Gregory H. Babunovic, Sanne van der Niet, Marco Túlio Pardini Gontijo…·David Branch Moody
The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.
Hannah E. Johnston, Sarah M. Batt, Alistair K. Brown…·Klaus Fütterer
This paper reports the cryoEM structure of M. tuberculosis Pks13, revealing its homodimeric architecture and providing insights into its catalytic mechanism.
Aaron Franklin, Vivian Carolina Salgueiro, Abigail J. Layton…·Patrick Joseph Moynihan
This study identifies LamH, a glycoside hydrolase that cleaves -1,6-mannoside linkages in LAM/LM, enabling their export to the capsule and promoting bacterial growth.
Vipul Navinchandra Panchal, Nidhi Jatana, Anchal Malik…·Vivek Rao
The paper identifies a mutation in the papA2 gene of Mycobacterium tuberculosis that leads to loss of sulfolipids by disrupting protein stability and structure.