Li Shen

This study uses a novel cell replacement strategy to show that the paternal genome is critical for neural development through Dlk1-mediated regulation of Notch signaling.

The paper identifies two distinct GABAergic neuron subtypes in the zona incerta that mediate different innate behaviors through specific projections.

This study shows that CXXC1 interacts with FOXP3 to regulate Treg cell function and epigenetic stability, essential for immune homeostasis and preventing inflammation.

scART is a tool for analyzing scATAC-seq data that identifies cell clusters and constructs developmental trajectories, demonstrating effectiveness in mouse embryonic forebrain data.

The paper identifies genome-wide decoupling of H2Aub and H3K27me3 in early mouse development, showing their distinct and independent functions.

The paper investigates how relaxed 3D genome conformation during the pluripotent-to-totipotent transition in mouse ESCs facilitates totipotency acquisition through changes in chromatin structure and enhancer dynamics.