Lianji Xue

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

PELSA-Decipher processes and interprets PELSA data to extract ligand-protein interaction details like binding proteins, sites, and affinities.

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.