Nan Shen

The paper experimentally measures CTCF-binding affinity across 276,765 human DNA sequences and develops a deep learning model to predict and interpret binding strength based on sequence features.

Phen2Disease prioritizes diseases and genes using phenotype similarity scores calculated from HPO terms, outperforming existing methods in cohorts with fewer HPO terms.

The paper identifies a dysfunctional enhancer linked to IRF8 expression through CRISPRa screening and shows its regulation by a lncRNA and DNA methylation.

This study identifies 38 novel SLE loci and shows genetic heterogeneity across ancestral groups, highlighting antibody production as a potential mechanism for disease disparities.

The paper identifies a non-coding genetic variant associated with SLE that regulates miR-146a expression through a cell-type specific enhancer.

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.