Parastoo Azadi

This study performs N-glycoproteomic profiling of Ancylostoma ceylanicum, identifying stage-specific glycoproteins and phosphorylcholine-modified glycans in larval and adult parasites.

This paper identifies GAUT13 and GAUT14 as enzymes that synthesize RG-I:HG heteroglycans and reveals a motif enabling functional domain swapping in glycosyltransferases.

This study identifies host factors critical for ssRNA and ssDNA phage infection in E. coli, revealing conserved dependencies and lineage-specific requirements.

This study identifies 13 genes essential for extreme colistin resistance in Pseudomonas aeruginosa using transposon insertion sequencing and validates novel pathways contributing to resistance.

This study shows that some GBS patients retain anti-ganglioside antibodies years after recovery, which no longer damage neurons but may still offer protection against C. jejuni.

This study identifies EpaU as an autolysin that binds the enterococcal polysaccharide antigen and modulates c-di-AMP signaling, affecting antibiotic resistance and cell turgor in Enterococcus faecalis.

The paper shows a trade-off between competitive ability and host colonization in Pseudomonas populations has persisted for centuries.

The paper identifies multi-factorial regulatory networks governing placental antibody transfer, showing how Fc receptor expression, IgG subclass, and clinical covariates interact to influence transfer efficiency.

This study identifies mucin-related proteins and novel sulfated polysaccharides as the main components of ctenophore mesoglea, revealing differences in ECM physiology compared to other metazoans.

This paper develops a method to determine site-specific O-acetylation in RG-I oligomers using deuterated acetyl groups and tandem mass spectrometry.

This paper shows GAUT1 synthesizes HG in Arabidopsis, which is tightly bound to the cell wall and essential for cell expansion.

This study identifies gram-positive bacterial cell wall components, such as peptidoglycan and lipoteichoic acid, as inhibitors of HSV-1 and HSV-2 infection in vitro and in a mouse model.

The paper provides a detailed structural analysis of rhamnogalacturonan-I in Arabidopsis, revealing novel structural features including O-acetylation of rhamnose residues.

The paper investigates whether pigments contribute to light color variation in fireflies, finding that ommochrome and pterin pigments may filter luciferase light but no significant gene expression differences were found between color variants.

This study identifies a conserved glycan motif in Streptococcus suis that elicits broadly reactive antibodies, suggesting it as a target for next-generation vaccines.

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

The paper identifies teichuronic acid oligosaccharides as the receptor for umbrella toxins and shows targeting specificity arises from lectin domain recognition of variable TUA-WTA structures.

This study shows that glycoengineering of HCV E2 glycoprotein affects antigen biochemical properties and immune response, with some glycans improving neutralization potency.

This study identifies the structure and biosynthesis mechanism of Streptococcus mutans cell wall polysaccharide, revealing key modifications and their roles in bacterial morphology and biofilm formation.

The paper identifies regulatory elements and protein substrates of lysine acetoacetylation, revealing its role in cellular processes and epigenetic regulation.

The paper identifies a single-subunit oligosaccharyltransferase from Desulfovibrio marinus that enables glycosylation of full-length IgG antibodies in E. coli.

The paper identifies a novel exopolysaccharide (EPS) pathway in Sphingomonas sp. LM7, showing it produces a unique linear polymer with 3- and 4-linked glucose, galactose, and glucuronic acid residues.

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.