Lu Lu

This paper introduces TopoVelo, a method to infer spatial and temporal dynamics of cell fate transitions from spatial transcriptomic data, improving spatial coherence and accuracy in cell differentiation and migration analysis.

This study identifies lung CD4+ resident memory T cells and their interaction with airway secretory cells as key regulators of neutrophilic allergic airways disease in mice and humans.

The paper characterizes CXCL12-expressing mesenchymal stromal cells and their role in supporting antibody-secreting cell niches in rejecting lung allografts.

The paper develops a novel murine model to identify genetic modifiers of triple-negative breast cancer traits and identifies susceptibility loci with potential translational relevance.

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

This study identifies Enc1's association with cognitive function in the hippocampus using systems genetics approaches in BXD mice.

The paper identifies a quantitative trait locus on chromosome 13 associated with STR expansion propensity in mice, implicating Msh3 in genome-wide mutation patterns.

The paper identifies a natural mutator allele in mice that increases C>A germline mutations by 50% due to a variant of the Mutyh gene.

PyLiger provides a Python implementation of the LIGER method for integrating single-cell multi-omic data, offering faster performance and new features.

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

The paper identifies Tti2 as a gene influencing both adult hippocampal neurogenesis and serum glucose levels using a rat genetic model.

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

The paper uses high-resolution imaging and QTL analysis to study genetic control of bone microarchitecture in mice, identifying 50 candidate genes with potential roles in bone biology.

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.

The paper generates high-resolution genetic maps of mouse inbred strains and identifies genetic variations and gene conversions.