Alan Wainman

This study investigates the structural differences in mitotic-centrosome assembly between Drosophila and C. elegans, showing divergent mechanisms involving Cnn and SPD-5 proteins.

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.

This study identifies Mob4 as essential for male fertility in Drosophila by regulating spermatid individualization and axonemal structure.

The paper identifies an autonomous Plk4 oscillator at the base of growing centrioles in Drosophila embryos that times and sets centriole biogenesis duration, independent of the cell cycle.