Author

Eleanor M Denham

University of OxfordORCID 0000-0002-6434-1993Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Angharad LloydiD· 1 shared Anthony Wayne PurcelliD· 1 shared Colin Moore· 1 shared Duncan HowieiD· 1 shared Emily P.S. Lam· 1 shared Giulia Masi· 1 shared Gurdyal Singh BesraiD· 1 shared Jamie RossjohniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Angharad LloydORCID

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2 papers

Recent·Most cited

Cancer BiologyFrontiers in OncologyPeer-reviewedOct 3, 2024

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

Terri V Cornforth, Nathifa A. Moyo, Suzanne Cole…·Joseph D. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

14 citations

humanexperimental assay

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ImmunologyCommunications BiologyPeer-reviewedSep 13, 2024

Ligand requirements for immunoreceptor triggering

Michael I. Barton, Rachel L. Paterson, Eleanor M. Denham…·Philip Anton van der Merwe

This study investigates ligand requirements for NTR triggering by varying ligand length, mobility, and valency, finding that size-based segregation, not clustering or mechanical force, is more consistent with the kinetic-segregation model.

1 citation

experimental assaycell signaling & trafficking

𝕏 PostBluesky