Daniel Roberto Perez

This study shows that H5N1 viruses from B3.13 and D1.1 lineages have reduced infectivity in human respiratory cultures due to impaired neuraminidase and polymerase activities, suggesting lower pandemic risk than traditional models indicate.

This study examines how maternal antibodies and weaning stress affect piglets' susceptibility to human H3N2 influenza A virus, showing that matched maternal antibodies reduce shedding and transmission while weaning increases viral spread.

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

This study shows that serial passage of a human-origin H3N2 virus in swine tracheal epithelial cells selects for adaptive HA mutations that increase viral fitness in swine cells.

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

This study shows that dispersal within the respiratory tract affects viral genetic diversity and evolutionary potential, with nasal and tracheal regions maintaining diversity while lung regions show genetic distinctness.

This study shows that reassorting the nucleoprotein gene in H3 influenza A viruses improved transmissibility in swine, but transmission efficiency depends on multiple genes.

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.