Cancer BiologyNature CommunicationsPeer-reviewed
An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development
Athina Varveri, Miranta Papadopoulou, Zacharias Papadovasilakis…·Panayotis Verginis
This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.
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