Author
Weill Cornell MedicineORCID 0000-0002-6608-5778Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Hui–Hsuan Kuo, Bhavneet Bhinder, Hamza Numan Gokozan…·M. Laura Martín
This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.
Florencia P. Madorsky Rowdo, Rachel N. Martini, Sarah E. Ackermann…·M. Laura Martín
The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.
Majd Al Assaad, Kevin Hadi, Max Fine Levine…·Juan Miguel Mosquera
The paper analyzes whole-genome sequencing data from a pan-cancer cohort to define HRD, showing it extends beyond BRCA1/2 mutations and highlights the benefits of WGS over commercial assays for HRD detection.
Jorge Azpurua, Enas A. Elkarim, Marvel Tranquille, Josh Dubnau
The paper identifies SF2/SRSF1 as a suppressor of TDP-43 toxicity in both neurons and glia through a Drosophila behavioral screen.