Jonne A. Raaijmakers

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

The paper identifies genes critical for the replication stress response in human cells, revealing both known and novel factors that protect against replication stress-induced toxicity.

This study shows that aneuploid cancer cells adapt by reducing chromosomal instability and inflammation, with KRAS amplification aiding this adaptation.

This study shows that condensin complexes use opposing ATPase sites to drive and dampen chromosome condensation, with condensin II playing a key role in decatenation and axis formation.