Steffen Grosser

This paper develops a minimal physical model to explain haptotaxis and oscillatory cell migration by linking adhesion strength to protrusive actin activity.

This study shows cells exhibit complex migration patterns along haptotactic gradients, including oscillations and directed movement, and develops a biophysical model to explain these behaviors.

This paper designs and implements synthetic gene circuits to program axial elongation in mammalian cell aggregates by controlling proliferation, tissue fluidity, and cell-cell signaling.

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.