Leone Rossetti

This study shows cells exhibit complex migration patterns along haptotactic gradients, including oscillations and directed movement, and develops a biophysical model to explain these behaviors.

This study investigates the functional effects of ALK variants in neural crest cells, showing that ALKF1174L increases migration and cytoskeletal protrusions through GSK3 binding.

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.