Juan Francisco Abenza

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.