Andreas Christian Hocke

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

The paper develops a 3D lung organoid model to assess antiviral T cell efficacy in vitro, demonstrating T cell-mediated cytotoxicity against influenza virus.

This study investigates how phage-phage competition and biofilm formation affect the efficacy of a two-phage combination against Pseudomonas aeruginosa in vitro.

This paper infers the connectivity of alveolar capillary networks from blood flow dynamics using computational models and simulations.

This study shows that IGF1R deficiency worsens pneumococcal pneumonia in mice, with increased lung damage and bacterial load, suggesting IGF1R has a protective role.

VoltRon is an R package for spatial omics analysis that integrates multi-resolution and multi-omics data through image registration and spatial alignment.

This study uses single-nuclei transcriptomics to analyze human kidney injury responses, identifying four injury-associated cell states and showing similar gene expression changes between AKI patients with and without COVID-19.

The paper uses bulk and single-cell transcriptomics to analyze SARS-CoV-2 infection in human cell lines, identifying HSP90 as a potential therapeutic target.