Martin Witzenrath

This study shows that high tidal volume ventilation acidifies alveolar lining fluid, increasing susceptibility to Pseudomonas pneumonia by reducing NHE1 expression.

This study identifies CXCL5 as a factor that increases alveolar-epithelial barrier permeability in acute lung injury, independent of neutrophil recruitment.

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.

This study investigates how phage-phage competition and biofilm formation affect the efficacy of a two-phage combination against Pseudomonas aeruginosa in vitro.

This study shows that pneumonia increases glucagon levels, which damages endothelial cells and promotes blood clotting, leading to cardiovascular issues.

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

This study shows that IGF1R deficiency worsens pneumococcal pneumonia in mice, with increased lung damage and bacterial load, suggesting IGF1R has a protective role.

This study shows that enzymatic degradation of hyaluronan and heparan sulfate in the lung worsens Streptococcus pneumoniae infection by increasing inflammation, bacterial burden, and barrier disruption in mice and human models.

This study evaluates a synthetic mRNA encoding a hyperactive Ang1 fusion protein to prevent pulmonary vascular leakage in lung injury models.

The paper evaluates dexamethasone and anti-SARS-CoV-2 antibodies in hamster models, showing reduced viral burden with antibodies and anti-inflammatory effects with dexamethasone, with synergistic benefits when combined.