Author
Monash UniversityORCID 0000-0002-6942-785XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Cyntia Taveneau, Her Xiang Chai, Jovita D’Silva…·Gavin J. Knott
This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.
Roland W. Calvert, Brooke K. Hayes, Her Xiang Chai…·Gavin J. Knott
The paper determines the structure of tRNA-bound CRISPR-Cas13 and reveals universal HEPN RNase mechanisms for substrate recognition and catalysis.
Valeriya Bezkorovayna, Brooke K. Hayes, Francesca N. Gillett…·John D. Boyce
This study identifies the molecular function and delivery determinants of the T6SS effector Tae17 in Acinetobacter baumannii, showing it is a bifunctional peptidoglycan hydrolase with lytic transglycosylase and amidase activities.
Brooke K. Hayes, Marina Harper, Hariprasad Venugopal…·Sheena McGowan
The paper presents the structure of Tse15, a T6SS Rhs effector from Acinetobacter baumannii, revealing a novel mechanism for toxin delivery and activation involving auto-cleavage and domain interaction.
Nyssa Drinkwater, Wei Yang, Blake T. Riley…·Sheena McGowan
This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.