MicrobiologyPLoS PathogensPeer-reviewed
Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo
Carolin M. Lieber, Hae‐Ji Kang, Megha Aggarwal…·Richard Karl Plemper
This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.