Jinghui Luo

This study uses β-barrel domain swapping to engineer α-hemolysin nanopores with enhanced single-molecule sensing capabilities.

This study shows how spermine modulates aggregation of Tau, α-synuclein, and Aβ40 by residue-specific interactions, revealing that net charge alone cannot predict its effects.

This study identifies a redox mechanism in human serum albumin (HSA) that reduces Cu(II) to Cu(I) via disulphide bonds and conformational changes, revealing a new role for protein-mediated copper regulation.

This paper designs a synthetic peptide mimicking Hsp90-Tau interaction to inhibit Tau aggregation and restore its microtubule binding, showing efficacy in vitro and in cells.

This study investigates how salt concentration affects the phase separation and aggregation of alpha-synuclein, revealing distinct salt dependencies and dynamic transitions between assembly states.

The paper uses a CRISPRi screen in human iNeurons to identify novel FCD genes that increase mTOR signaling, finding two genes mutated in FCD patient tissue.

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

This study identifies a shared mechanism of increased lumen size due to reduced apical constriction in brain organoids caused by valproic acid and SHROOM3 knockout.

The paper identifies a transcriptional signature of glomerular disease using single-cell profiling of human kidney organoids and validates it in disease cohorts.