Matthew S. Waitkus

This study develops a mouse model of Ppm1d mutations in gliomas, showing they deregulate the p53 pathway, promote gliomagenesis, and increase radiosensitivity and PARP inhibitor vulnerability.

This study shows that loss of Atrx in a mouse sarcoma model activates the ALT telomere maintenance pathway independently of telomerase, leading to telomere instability and APB formation.