Alessandro Scopelliti

This study uses proteomic analysis to reveal reprogramming in macrophages during efferocytosis, showing an alternatively activated phenotype and secretome-driven reprogramming of naive macrophages.

The paper identifies hypoxanthine as a key metabolite released during apoptosis that is consumed by gut bacteria, impairing epithelial repair.

The paper shows that larval oenocytes in Drosophila die by apoptosis regulated by ecdysone and E75, revealing how systemic hormones control cell death in metabolic organs.