Gregory C. Ippolito

This study compares the pathogenicity and transmissibility of two H5N1 genotypes in ferrets, finding B3.13 is more pathogenic and transmissible than D1.1, while D1.1 acquires adaptive mutations rapidly.

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

The paper identifies synergistic non-neutralizing antibodies against PfRH5 that enhance malaria parasite growth inhibition when combined with neutralizing antibodies.

This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.

This study shows that a combination of antibodies targeting both the SARS-CoV-2 spike protein's receptor binding domain (RBD) and stem helix (SH) domains prevents the emergence of viral escape mutants.

This study examines the B cell receptor repertoire and antibody responses after 17DD-YF vaccine boosting, finding a transient antibody response with limited neutralization capacity and rapid clonal expansion of IgA and IgG isotypes.

This study shows that the R21/Matrix-M malaria vaccine induces specific IgG antibodies targeting multiple CSP epitopes, contributing to its efficacy against P. falciparum malaria.

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

The paper identifies SARS-CoV-2 neutralizing antibodies from convalescent patients and describes a novel quaternary binding mechanism using high-throughput methods.