George Georgiou

The paper uses cryo-ET to show serum IgM crosslinks HBV SVPs into supramolecular immune complexes through multivalent Fab interactions.

This study uses Fc-engineered antibodies to selectively engage FcγRIIa or FcγRI, revealing their distinct effector functions in human monocytes and macrophages.

This study shows that methionine restriction induces ferroptosis in EBV-transformed B cells by promoting transsulfuration and glutathione synthesis, and that targeting methionine metabolism can impair tumor growth.

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

This study shows Fc-silencing mutations in therapeutic antibodies do not block FCRL5 binding, potentially affecting B cell function through novel Fc-FCRL5 interactions.

The paper identifies synergistic non-neutralizing antibodies against PfRH5 that enhance malaria parasite growth inhibition when combined with neutralizing antibodies.

This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.

This paper engineers IgG1 antibodies with modified Fc domains to resist viral Fc receptor binding, enhancing NK cell activation and reducing HCMV spread in infected cells.

This study shows that the R21/Matrix-M malaria vaccine induces specific IgG antibodies targeting multiple CSP epitopes, contributing to its efficacy against P. falciparum malaria.

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

The paper identifies SARS-CoV-2 neutralizing antibodies from convalescent patients and describes a novel quaternary binding mechanism using high-throughput methods.