Michael S. Westphall

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.

This paper introduces a modified mass spectrometry system for depositing gas-phase protein complexes onto EM grids, enabling 3D structure determination of non-covalent protein complexes like GroEL.

The paper integrates proteomics, lipidomics, metabolomics, and 16S rDNA sequencing to analyze dental plaque from patients with diabetes and periodontal disease, identifying microbial and host factors associated with these conditions.

The paper introduces AI-ETD for MS-based proteomics analysis of physiological ADP-ribosylation, identifying more ADPr sites than existing methods.

This study captures site-specific N-glycoproteome heterogeneity using AI-ETD, identifying 1,545 N-glycosites from mouse brain tissue and developing new visualizations for glycopeptide analysis.