Katherine A. Overmyer

This paper links maternal high-fiber diet to reduced offspring type 2 diabetes risk through multi-tissue transcriptomic and metabolomic analyses in Nile rats, identifying ASNSD1 as a key gene involved.

The paper identifies strain-specific GRA5 polymorphisms in T. gondii using proteomic analysis of cerebrospinal fluid from reactivated toxoplasmosis cases, suggesting a proteotype for strain risk stratification.

The paper presents a comprehensive atlas of lysine acetylation in the mouse, identifying 17,952 sites across 15 tissues and highlighting shared and tissue-specific acetylation events.

The paper investigates how emitter positioning affects peptide signal intensity in nanoflow electrospray ionization for proteomics, finding consistent signal behavior across m/z range.

This study examines how drought at different developmental stages affects switchgrass physiology, metabolism, and biofuel yield, finding that vegetative-stage drought increases resilience but reduces biofuel production.

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

This study uses machine learning to identify gene families associated with oxidative stress resistance in yeasts and validates their roles experimentally.

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

This paper evaluates six plasma proteomic technologies, finding that Seer Proteograph XT provides the highest proteomic depth and quantification, while Olink Explore HT shows comparable LOD but worse LOQ.

This study shows that adjusting pH and using SAA pretreatment improves biofuel production from drought-switchgrass hydrolysates.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This study uses nMOST to profile proteo-lipidomics in lysosomal storage disease mutants, revealing autophagy defects and mitochondrial dysfunction.

The paper develops SPE-CZE-MS for quantifying phosphorylated peptides in single-cell equivalent phosphoproteomics, demonstrating improved sensitivity and compatibility with mass spectrometry.

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

This study shows that SCD1 and monounsaturated lipids are essential for autophagy and survival of adipocytes, with SCD1 deficiency causing autophagosome accumulation and cell death.

The paper investigates how PKA signaling coordinates growth and metabolism in yeast during anaerobic xylose fermentation by analyzing transcriptomic, lipidomic, and phosphoproteomic data.

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

This study identifies genetic links between gut microbiota, lipids, and host transcripts in mice, revealing key roles for Akkermansia muciniphila and ornithine lipids in microbe-host interactions.

The paper integrates proteomics, lipidomics, metabolomics, and 16S rDNA sequencing to analyze dental plaque from patients with diabetes and periodontal disease, identifying microbial and host factors associated with these conditions.