Author

Craig R. Garen

University of AlbertaORCID 0000-0002-7772-9890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Organism:rat· 1 Organism:zebrafish· 1

Frequent Co-Authors

Michael T. WoodsideiD· 2 shared Shubhadeep PatraiD· 2 shared Rohith Vedhthaanth SekariD· 1 shared Uttam AnandiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

Michael T. WoodsideORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 28, 2026

Quantifying the binding affinity of a pharmacological chaperone to transient unfolded states of a normally folded protein

Shubhadeep Patra, Craig R. Garen, Michael T. Woodside

This study quantifies the binding affinity of a pharmacological chaperone to unfolded states of a normally folded protein using single-molecule force spectroscopy.

DOI 10.64898/2026.08.27.747683

experimental assay

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedJul 14, 2025

Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level

Uttam Anand, Shubhadeep Patra, Rohith Vedhthaanth Sekar…·Michael T. Woodside

The paper compares single-molecule folding dynamics of PrP from three mammalian species with different disease susceptibility, revealing sequence-driven differences in folding pathways and misfolding propensity.

2 citations

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