Kenneth A. Stapleford

This study identifies the M segment of La Crosse virus as a key determinant of cell-to-cell spread, virulence, and plaque size across different viral isolates.

This study shows that the Gc glycoprotein head and stalk domains are essential for virion assembly in insect hosts but not in mammalian cells, explaining their conservation in nature.

The paper identifies antiviral resistance mutations in chikungunya virus envelope proteins that reveal a transient functional interaction between distal domains during fusion.

This study identifies the La Crosse virus Gc head domain as critical for viral replication, dissemination, and pathogenesis in mice.

This study investigates how different strains of chikungunya virus (CHIKV) and related alphavirus Mayaro virus (MAYV) infect human cardiac endothelial cells, finding that CHIKV is restricted at multiple stages while MAYV evades restriction more effectively.

This study identifies key residues in the CHIKV nsP4 polymerase palm and ring finger domains that influence replication, genetic stability, and assembly across different hosts.

This study uses genomic reassortment to identify how different segments of La Crosse virus affect infection and pathogenesis in vitro and in vivo.

This study investigates how mutations in the CHIKV E1 glycoprotein's fusion loop and hinge affect virus infectivity in different cell types and hosts by altering E1-E2 dynamics.